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US 5,707,964 AGranted
Method for treating cancer
AssigneeColorado State University Research Foundation
InventorsTorrance M. Nett, Leonard Michael Glode
Life of this patent
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AssigneeColorado State University Research Foundation
InventorsTorrance M. Nett, Leonard Michael Glode
Estimating the term…
Certain toxic compounds (T) such as, for example, compounds based upon diphtheria toxin, ricin toxin, pseudomonas exotoxin, .alpha.-amanitin, pokeweed antiviral protein (PAP), ribosome inhibiting proteins, especially the ribosome inhibiting proteins of barley, wheat, corn, rye, gelonin and abrin, as well as certain cytotoxic chemicals such as, for example, melphalan and daunomycin can be conjugated to certain analogs of gonadotropin-releasing hormone to form a class of compounds which, when injected into an animal, destroy the gonadotrophs of the animal's anterior pituitary gland. Hence such compounds may be used to sterilize such animals and/or to treat certain sex hormone related diseases.
A method for treating cancer in an animal, said cancer comprising cells having GnRH receptors, wherein said method comprises administering to said animal an effective amount of a hormone/toxin conjugate to destroy said cancer cells, said conjugate comprising a peptide hormone capable of selectively binding to cells having GnRH receptors conjugated to a toxin group capable of destroying said cancer cells.
Dependencies are inferred from the claim text.