Methods of using growth inhibitory peptides
AssigneeHealth Research, Inc.
InventorGerald J. Mizejewski
Life of this patent
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Abstract
The subject invention provides non-naturally occurring peptides capable of inhibiting growth factor-stimulated growth of cells. The peptide can be utilized to inhibit growth factor-stimulated growth, such growth factors including, for example, gonadotropins, peptide hormones, synthetic growth factors, and ligands, the ligand having a receptor that is a member of the steroid/thyroid hormone/vitamin receptor superfamily. Also provided are DNA sequences encoding the peptides and methods of producing and using the peptides.
Claims12
A method of inhibiting growth factor-stimulated growth of cells, said growth factor-stimulated growth being stimulated by a growth factor selected from the group consisting of estrogen, diethylstilbestrol, hydrocortisone, and human chorionic gonadotropin, said method comprising selecting a sample having cells therein capable of growth factor-stimulated growth, and contacting said sample with a peptide so as to inhibit growth factor-stimulated growth of said cells, wherein said peptide is a non-naturally occurring peptide having an amino acid sequence selected from the group consisting of SEQ ID NO:1 and SEQ ID NO:8.
A method of inhibiting growth factor-stimulated growth of cells, said growth factor-stimulated growth being stimulated by a growth factor selected from the group consisting of estrogen, diethylstilbestrol, hydrocortisone, and human chorionic gonadotropin, said method comprising selecting a sample having cells therein capable of growth factor-stimulated growth, and contacting said sample with a peptide so as to inhibit growth factor-stimulated growth of said cells, wherein said peptide is a non-naturally occurring peptide having an amino acid sequence selected from the group consisting of SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:9, SEQ ID NO:10, and SEQ ID NO:11.
Dependencies are inferred from the claim text.