DNA oligomers for inhibition of HIV by decreasing ribosomal frameshifting
AssigneeUniversite de Montreal
InventorsLea Brakier-Gingras, Pierre Melan.cedilla.on, Marc Cote, Catherine Payant
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Abstract
The invention relates to the use of antisense DNA oligomers to decrease the occurrence of ribosomal frameshifting required for the production of HIV enzymatic proteins when translating HIV messenger RNA, which should interfere with the production of virions and disrupt HIV life cycle. The antisense DNA oligomers are complementary to regions of the RNA of the small ribosomal subunit of mammalian cells, which are involved in the control of translation fidelity.
Claims5
An antisense DNA oligomer which is complementary to the region of the human 18 S rRNA consisting of nucleotides 595 to 641, wherein said oligomer decreases the occurrence of ribosomal frameshifting and inhibits the expression of HIV enzymatic proteins.
An antisense oligomer having the sequence of SEQ ID NO:9.
Dependencies are inferred from the claim text.