Tumor suppressor gene merlin
AssigneeThe General Hospital Corporation
InventorsJames A. Trofatter, Mia M. MacCollin, James F. Gusella
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Abstract
A novel tumor suppressor protein, merlin, is described, including DNA sequences encoding merlin, and recombinant vectors and hosts capable of expressing merlin. Method for the diagnosis and treatment of merlin-associated tumors, and for the diagnosis and treatment of the disease neurofibromatosis 2 (NF2) are also provided.
Claims8
An isolated merlin gene, wherein said merlin gene encodes a protein having rumor suppressor activity.
A mutant merlin gene comprising an A.fwdarw.T transversion at the first base encoding amino acid 220 of the amino acid sequence shown in SEQ ID NO:
- 15.
A mutant merlin gene comprising a mutation associated with neurofibromatosis-2.
An isolated DNA molecule comprising a nucleotide sequence selected from the group consisting of:
- (1) a first sequence encoding the amino acid sequence shown in SEQ ID NO:
- 15;
- (2) a second sequence complementary to said first sequence;
- and (3) fragments of said first sequence or said second sequence that are of sufficient length to identify a clone containing the merlin gene via hybridization.
Dependencies are inferred from the claim text.