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US 5,707,831 AGranted
Process for preparing recombinant aprotinin and recombinant aprotinin variants having the natural N-terminal sequence
AssigneeBayer Aktiengesellschaft
InventorsHeiner Apeler, Jurgen Beunink, Michael Dorschug, Uwe Gottschalk
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Abstract
The invention relates to a process for preparing recombinant aprotinin and recombinant aprotinin variants having the natural N-terminal sequence, with the recombinant aprotinin and/or the recombinant aprotinin variants being present as homogeneously processed, secreted proteins.
Claims2
A vector for expressing in yeast cells aprotinin and aprotinin variants having a correct N terminus, said vector comprising:
- a) the gene for the aprotinin or the variant, and
- b) as a leader directly upstream of this gene, the nucleotide sequence for the yeast a Mating Factor signal sequence.
Dependencies are inferred from the claim text.