Loading patent…
AssigneeCreative BioMolecules, Inc.
InventorsJohn E. Smart, Hermann Oppermann, Engin Ozkaynak, Thangavel Kuberasampath, David C. Rueger, Roy H. L. Pang, Charles M. Cohen
Estimating the term…
In one aspect, the present invention provides a method of diagnosing renal tissue damage or disease by measuring endogenous expression of OP-1 by renal tissue of a mammal (e.g., a human) in which a depression of endogenous expression relative to undamaged or undiseased mammalian renal tissue indicates a diagnosis that the mammal is afflicted with renal tissue damage or disease. Also disclosed are methods of diagnosing renal tissue damage or disease in a mammal. The methods involve detecting and/or measuring the expression of the OP-1 (BMP-7) gene or protein in the mammal. Depression of OP-1 expression may be used to diagnose renal tissue damage or disease.
A method of diagnosing renal tissue damage or disease comprising the step of measuring endogenous expression of OP-1 by renal tissue of a mammal, wherein a depression of said endogenous expression relative to undamaged or undiseased mammalian renal tissue indicates a diagnosis that said mammal is afflicted with said damage or disease.
A method of diagnosing renal tissue damage or disease comprising the steps of:
A method of diagnosing renal tissue damage or disease comprising the steps of:
Dependencies are inferred from the claim text.