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US 5,707,656 AGranted
Pharmaceutical formulations containing a pharmacologically active ionizable substance as well as process for the preparation thereof
AssigneeAstra Aktiebolag
InventorsBengt Magnus Lindstedt, Per Johan Gunnar Lundberg
Life of this patent
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Abstract
A preparation of a pharmacologically active ionizable substance, wherein active substance is ionically complexed to an ion-exchanger resin, which is embedded in a hydrophilic eroding matrix as well as a process for the manufacture thereof.
Claims6
An oral pharmaceutical composition for extended even release of an ionizable active substance comprising:
- an ionizable acidic active substance having a water solubility of more than 10 mg/ml;
- an ionizable acidic active substance;
- an ionic exchange resin consisting of a cross-linked polymer ionically complexed with the acidic active substance so as to form an ionic complex, which is embedded in a hydrophilic eroding matrix consisting of derivatized cellulose.
An oral pharmaceutical composition for extended even release of ionizable active substance comprising:
- an ionizable basic active substance having a water solubility of more than 10 mg/ml, selected from the group consisting of metoprolol and terbutaline;
- a cation-exchange resin which is a cross-linked polymer and which is ionically complexed with the basic active substance so as to form an ionic complex;
- the ionic complex being embedded in a hydrophilic eroding matrix consisting of derivatized cellulose.
Dependencies are inferred from the claim text.