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US 5,707,655 AGranted
Process for the preparation of medicament formulations with controlled release
AssigneeBayer Aktiengesellschaft
InventorsVenkata-Rangarao Kanikanti, Stefan Kettelhoit, Peter Kurka, Gunther Penners, Peter Serno
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Abstract
The invention relates to a special process for the preparation of stable, solid medicament formulations of high bioavailability and with controlled release comprising sparingly soluble active compounds and polymeric auxiliaries, and to the formulations thus prepared.
Claims9
A process for preparing a controlled release, solid medicament formulations which possess high stability, said process comprises:
- A. mixing in the absence of solvents at least three components which comprise
- at least one part by weight of a sparingly soluble and heat-stable active compound (I);
- 0.5 to 50 parts by weight of a cellulose ether (II);
- and
- 0.5 to 50 parts by weight of a polyoctam or polyvinyllactam copolymer (III)
- B. shaping the solid mixture obtained above to give the desired medicament formulation;
- and
- C. heating the shaped formulation obtained above at a temperature between 50.degree. and 200.degree. C. for at least 30 minutes to achieve thermal dissolution or amorphization of the active compound.
5 more elements
Dependencies are inferred from the claim text.