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AssigneePharmaderm Research & Development Ltd.
InventorsAvi Gertner, Yosef Rubinstein
Estimating the term…
A pharmaceutical formulation which is adapted particularly for transdermal administration, and which comprises an aqueous emulsion or dispersion including, in addition to the aqueous phase, at least ingredients (a) and (b) of ingredients (a), (b) and (c): (a) as active ingredient, at least one therapeutically active protein or polypeptide; (b) at least one pharmaceutically acceptable emulsifier; (c) an oil phase comprising or consisting essentially of at least one ester of an aliphatic hydroxy compound containing 1-12 carbon atoms and 1-4 alcoholic hydroxy groups with an aliphatic carboxylic acid containing 8-24 carbon atoms and 1-3 carboxylic acid groups; provided that the therapeutic activity of the active ingredient in the formulation is such that the presence or the therapeutic effect of the active ingredient is detectable in the bloodstream within less than two hours after commencing transdermal administration, and further provided that when the active ingredient comprises insulin, the insulin is subjected to a pretreatment under predetermined conditions, prior to incorporation in the formulation.
A pharmaceutical formulation which is adapted particularly for transdermal administration, and which comprises an aqueous emulsion or dispersion including, in addition to the aqueous phase, at least the following ingredients (a), (b) and (c):
A pharmaceutical formulation which is adapted particularly for transdermal administration, and which comprises at least one carrier, diluent or adjuvant, together with insulin as active ingredient,
A pharmaceutical formulation which is adapted particularly for transdermal administration, and which comprises an aqueous emulsion or dispersion including, in addition to the aqueous phase, at least the following ingredients (a) and (b):
A pharmaceutical formulation which is adapted particularly for transdermal administration, and which comprises an aqueous emulsion or dispersion including, in addition to the aqueous phase, an active ingredient which comprises insulin which is stably dissociated into dimers and/or monomers and/or in which insulin-metal bonds are split or weakened, and substituted insulin or short-acting insulin preparations, wherein the therapeutic activity of said active ingredient is such that the presence or the therapeutic effect of said active ingredient is detectable in the bloodstream in less than two hours after commencing transdermal administration of said formulation.
Dependencies are inferred from the claim text.