Apparatus and method for preparing solid forms with controlled release of the active ingredient
AssigneeSaitec S.R.L.
InventorsLorenzo Rodriguez, Maurizio Cini, Cristina Cavallari, Giuseppe Motta
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Abstract
Controlled release solid forms, apparatus and method for preparing solid forms for controlled release of an active ingredient.
Claims10
Apparatus for preparing solid forms with controlled release of the active ingredient according to the spray drying and spray congealing techniques, characterized in that is comprises:
- a) an atomizing device utilizing mechanical vibrations of resonant metal elements or nozzles, that nebulizes in very little droplets a liquid comprising a solution, suspension or emulsion of one or more active ingredients and/or excipients in one or more solvents of different polarity or of one or more active ingredients in one or more melted waxy excipients;
- b) a cylindrical chamber with vertical axis inside of which the droplets thus obtained in a) fall to give spherical powder particles because of the evaporation of the contained solvents or of the solidification owing to the quenching of the melted waxy components, and
- c) a device for recovering the volatile solvents eventually employed.
Method for preparing solid forms with controlled release of the active ingredient, characterized in that a suspension, solution or emulsion of one or more active ingredients and/or excipients in one or more solvents of different polarity or of one or more active ingredients in one or more melted waxy excipients is fed on resonant metal elements or nozzles subjected to infrasonic, sonic or ultrasonic frequencies, the very small droplets thus obtained fall in a cylindrical chamber with vertical axis to give spherical powder particles, and the solvents eventually employed are recovered.
Dependencies are inferred from the claim text.