Adenovirus vectors for gene therapy
AssigneeGenzyme Corporation
InventorsDonna Armentano, Helen Romanczuk, Samuel Charles Wadsworth
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Abstract
The present invention relates to novel adenovirus vectors for use in gene therapy which are designed to prevent the generation of replication-competent adenovirus (RCA) during in vitro propagation and clinical use. The invention also provides methods for the production of the novel virus vectors. These vectors maximize safety for clinical applications in which adenovirus vectors are used to transfer genes into recipient cells for gene therapy.
Claims8
A recombinant adenovirus vector having a deleted E1 region of the adenovirus genome, into which a heterologous gene has been inserted, and in which the protein IX gene has been relocated in the adenovirus genome to a location thereof other than the location in which said protein IX gene normally resides, such that generation of replication-competent adenoviruses is minimized or eliminated.
Dependencies are inferred from the claim text.