Loading patent…
AssigneeAllergan, Inc.
InventorsAbhay Joshi, David Meadows, Jerry Paugh
Estimating the term…
Apparatus and method for measuring ophthalmic formulation retention on the surface of an eye include dissolving a fluorescent macromolecule in an ophthalmic formulation to form a fluorescently labelled formulation; topically administering the fluorescently labelled formulation to an eye, said fluorescently labelled formulation forming a thin film on the eye surface. Apparatus is provided for illuminating the eye to cause fluorescence of the fluorescently labelled formulation as the fluorescently labelled formulation thin film is eliminated from the eye by normal blinking and lacrimation; and for measuring fluorescence from the thin film as a function of time.
An ophthalmic formulation for measuring ophthalmic formulation retention in an eye, said ophthalmic formulation comprising a pharmaceutical agent for an eye and a fluorescent macromolecule having a molecular weight greater than about 2,000 Daltons.
An ophthalmic formulation for measuring ophthalmic formulation retention in an eye, said ophthalmic formulation comprising a pharmaceutical agent for an eye and a fluorescent macromolecule having a molecular weight greater than about 2,000 Daltons, the fluorescent macromolecule comprising fluorescent TRITC and nonfluorescent Dextran covalently bonded.
An ophthalmic formulation for measuring ophthalmic formulation retention in an eye, said ophthalmic formulation comprising an agent for sustaining release of other ocular pharmaceutical agents and a fluorescent macromolecule having a molecular weight greater than about 2000 Daltons.
Dependencies are inferred from the claim text.