Magnetic resonance imaging agents for the detection of physiological agents
AssigneeResearch Corporation Technologies, Inc.
InventorsThomas Meade, Scott Fraser, Russell Jacobs
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Abstract
The invention relates to magnetic resonance imaging agents comprising a paramagnetic metal ion bound to a complex wherein said complex comprises a chelator and a blocking moiety convalently attached to said chelator which binds in at least a first coordination site of said metal ion and which is capable of interacting with a target substance such that the exchange of water in at least said first coordination site is increased.
Claims16
A MRI agent comprising a paramagnetic metal ion bound to a complex, said complex comprising:
- a) a chelator;
- and
- b) a blocking moiety covalently attached to said chelator which binds in at least a first coordination site of said metal ion and which is capable of interacting with a target substance such that the exchange of water in at least said first coordination site is increased.
A MRI agent comprising
- a) a paramagnetic metal ion capable of binding n coordination atoms, wherein said metal ion is bound to a chelator such that said metal ion has coordination atoms at (n-1) or (n-2) coordination sites of said metal ion;
- and
- b) a blocking moiety covalently attached to said chelator that hinders the rapid exchange of water in the remaining coordination site or sites,
- wherein said blocking moiety is capable of interacting with a target substance, such that the exchange of water at the remaining coordination site or sites is increased.
A MRI agent having the formula comprising:
- ##STR21## wherein M is a paramagnetic metal ion selected from the group consisting of Gd(III), Fe(III), Mn(II), Yt(III), Cr(III) and Dy(III);
- A, B, C and D are either single bonds or double bonds;
- W, X, Y and Z are --OH, --COO--, --CH.sub.2 OH or --CH.sub.2 COO--;
- R.sub.1 -R.sub.12 are hydrogen, alkyl, substituted alkyl, phosphorus moiety, or a blocking moiety;
- wherein at least one of R.sub.1 -R.sub.12 is a blocking moiety.
A MRI agent having the formula comprising:
- ##STR23## wherein M is a paramagnetic metal ion selected from the group consisting of Gd(III), Fe(III), Mn(II), Yt(III), Cr(III) and Dy(III);
- A, B, C, and D are either single or double bonds;
- S, T, U and V are --OH, --COO--, --CH2OH, --CH2COO--, or a blocking moiety;
- R.sub.1 -R.sub.12 are hydrogen, alkyl, substituted alkyl, or phosphorus moiety;
- wherein at least one of S, T, U or V is a blocking moiety.
A MRI agent having the formula comprising:
- ##STR26## wherein M is a paramagnetic metal ion selected from the group consisting of Gd(III), Fe(III), Mn(II), Yt(III), Cr(III) or Dy(III);
- H, I, J, K and L are --OH, --COO--, --CH2OH, --CH2COO--, or a blocking moiety;
- R.sub.13 -R.sub.21 are hydrogen, alkyl, substituted alkyl, phosphorus moiety or a blocking moiety;
- wherein at least one of R.sub.13 -R.sub.21, H, I, J, K or L is a blocking moiety.
Dependencies are inferred from the claim text.