Anti-infective and antithrombogenic medical articles and method for their preparation
AssigneeBecton, Dickinson and Company
InventorsDonald D. Solomon, M. Parke Byron
Life of this patent
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Abstract
An anti-infective medical article has chlorhexidine bulk distributed throughout a polyurethane base layer and may have a coating layer on the base layer. The coating layer may be chlorhexidine permeated into the surface or it may be an antibiotic, antithrombogenic agent or a polymeric surface layer laminated onto the base layer. The invention includes a method for preparing the article wherein a homogeneous melt of polymer and chlorhexidine is prepared by twin screw compounding and the melt is extruded to give a medical article having bulk distributed chlorhexidine.
Claims47
A tubular medical article adapted for contacting with or inserting into living tissue, comprising a polymeric base layer having a water absorption of at least 0.6% by weight and a coating thereon, said base layer having a first increment of chlorhexidine bulk distributed throughout, and said coating including a second increment of chlorhexidine.
A tubular medical article adapted for placement in contact with or insertion into living tissue, comprising a polymer having a water absorption of at least 0.6% by weight and an anti-infective agent comprising a biguanide bulk distributed throughout.
A tubular medical article for contacting with or inserting into living tissue, comprising a polymeric base layer having a water absorption of at least 0.6% by weight and a coating layer, the coating layer comprising a laminating polymer having a water absorption of at least 0.6% by weight, said base and laminating layers each having about 0.1 to 10% by weight of a biguanide bulk distributed throughout.
Dependencies are inferred from the claim text.