Method for treating neurocardiogenic syncope
AssigneeCreighton University
InventorNazih Najih Kadri
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Abstract
The present invention relates to methods for treating neurocardiogenic syncope. The method involves administering to a patient an effective amount of a compound having the formula: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.5 are each selected from the group consisting of hydrogen and lower alkyl; and R.sub.3 and R.sub.4 are each selected from the group consisting of hydrogen, halogen, lower alkyl, nitro, amino, trifluoromethyl, and lower acylamino; at least one of R.sub.3 and R.sub.4 being a nitrogen containing group, or a pharmaceutically acceptable salt thereof.
Claims21
A method for treating neurocardiogenic syncope in a patient, said method comprising:
- administering to an adult from about 0.5 milligrams to about 1.5 kilograms per day, or to a child from about 0.01 milligrams per kilogram to about 0.05 milligrams per kilogram of the child's body weight per day, of a compound having the formula:
- ##STR10## wherein R.sub.1, R.sub.2 and R.sub.5 are each selected from the group consisting of hydrogen and lower alkyl;
- and R.sub.3 and R.sub.4 are each selected from the group consisting of hydrogen, halogen, lower alkyl, nitro, amino, trifluoromethyl, and lower acylamino;
- at least one of R.sub.3 and R.sub.4 being a nitrogen containing group,
- or a pharmaceutically acceptable salt thereof.
A method for treating neurocardiogenic syncope in an adult patient, said method comprising:
- administering to the adult patient from about 0.5 mg to about 1.5 mg per day of a compound having the formula:
- ##STR11## wherein R.sub.3 is halogen and R.sub.4 is selected from the group consisting of halogen, nitro, and trifluoromethyl
- or a pharmaceutically acceptable salt thereof.
The method of claim 16 wherein R.sub.3 is chlorine and R.sub.4 is nitro.
The method of claim 17 wherein the compound is clonazepam.
A method for treating neurocardiogenic syncope in a patient wherein the patient is a child, said method comprising:
- administering to the patient from about 0.01 mg/kg to about 0.05 mg/kg of the patient's body weight per day of a compound having the formula:
- ##STR12## wherein R.sub.3 is halogen and R.sub.4 is selected from the group consisting of halogen, nitro, and trifluoromethyl
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.