Process for the preparation of crystalline O-isopropylisourea hydrochloride
AssigneeSKW Trostberg Aktiengesellschaft
InventorStefan Weiss
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Abstract
Disclosed is a process for the preparation of crystalline O-isopropylisourea hydrochloride, wherein cyanamide, chloroformamidinium chloride and isopropanol are reacted, an aprotic solvent preferably selected from the group consisting of ketones, ethers, esters and acetals, is added to the reaction mixture before, during and/or after the reaction and, optionally after cooling the reaction solution, the crystalline reaction product is separated off. O-isopropylisourea hydrochloride is obtained in a very pure and coarse crystalline form by the process of the invention.
Claims16
A process for the preparation of crystalline O-isopropylisourea hydrochloride, comprising:
- (a) reacting cyanamide, chloroformamidinium chloride and isopropanol in a reaction mixture to form a crystalline reaction product;
- (b) adding an aprotic organic solvent to the reaction mixture before, during and/or after the reaction;
- and, (c) separating off the crystalline reaction product.
Dependencies are inferred from the claim text.