N-alkylation method of pyrazole
AssigneeNissan Chemical Industries, Ltd.
InventorYoshio Ono
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Abstract
An N-alkylation method of pyrazole in which (III) is produced from (I) and (II), which is characterized by using a crystalline aluminosilicate or a crystalline aluminophosphate as a catalyst: ##STR1## wherein each of R.sup.1, R.sup.2 and R.sup.3 represents hydrogen, alkyl, alkenyl or phenyl, R represents alkyl and Q represents hydrogen, alkyl or COOR. This is an industrially markedly useful method, because (III) can be obtained with a high yield under mild reaction conditions, and by-products including salts are not at all formed.
Claims22
A method for producing an N-alkylpyrazole compound represented by the formula (III):
- ##STR6## wherein each of R.sup.1, R.sup.2 and R.sup.3 is independently selected from the group consisting of a hydrogen atom, a C.sub.1-20 alkyl group, a C.sub.2-20 alkenyl group, a cyclopropyl group, a cyclobutyl group, a cyclopentyl group, a cyclohexyl group, a cyclooctyl group, a cyclopropylmethyl group, a cyclobutylmethyl group, a cyclopentylmethyl group, a cyclohexylmethyl group, a benzyl group, a 1-phenethyl group, a 2-phenethyl group, a 3-phenylpropyl group, a cinnamyl group, and a phenyl group, from a pyrazole compound represented by the formula (I):
- ##STR7## wherein each of R.sup.1, R.sup.2 and R.sup.3 is as defined in the formula (III) above, and an alcoholic compound represented by the formula (II):
- R--O--Q (II)
- wherein R represents a C.sub.1-20 alkyl group and Q represents a hydrogen atom, a C.sub.1-20 alkyl group or a COOR group, wherein N-alkylation of said pyrazole compound is carried out using a crystalline aluminosilicate or a crystalline aluminophosphate as a catalyst.
Dependencies are inferred from the claim text.