US 5,705,655 AGranted

Amphiphilic nitrogen containing imidazolinium derivative compounds and uses

AssigneeMegabios Corporation

InventorsTimothy D. Heath, Igor Solodin

Life of this patent

Estimating the term…

Abstract

Amphiphiles containing an imidazdinium ring system are provided that are non-toxic to the host mammal. The amphiphiles are used to produce liposomes useful as carriers for delivering macromolecules intracellularly.

Claims11

Dependent claims

A nitrogen-containing amphiphile of the formula:

##STR6## wherein each R and R.sub.1 independently is a straight-chain, aliphatic hydrocarbyl group of 11 to 29 carbon atoms inclusive.

Dependencies are inferred from the claim text.

Facts

Application: 08/247,963Filed 24 May 1994 · continuation in part
Priority: 17 Dec 1992
Granted: 6 Jan 1998
Term ends: Not estimatedThe source records don’t support an estimate.

Classification11 codes

C07D 233/56
Having two double bonds between ring members or between ring members and non-ring members: with only hydrogen atoms or radicals containing only…
A61K 9/1272
Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers: comprising non-phosphatidyl surfactants as…
A61K 47/6801
The modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment: drug-antibody or immunoglobulin conjugates…
C07C 279/08
Having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton: being further substituted by singly-bound oxygen atoms

Family

Serial991,935Parent of this continuation-in-part · filed 17 Dec 1992
Serial157,727Parent of this continuation-in-part · filed 24 Nov 1993
US 5,705,655 AThis patent

From the US filing history. Foreign family members aren’t listed.

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