Preparation of substituted thiazoles
AssigneesFine Organics Limited, Agro-Kanesho Co., Ltd.
InventorsArthur Jackson, Graham Heyes, James Ian Grayson, Russell Clarke
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Abstract
A process for the preparation of a substituted thiazole comprises reacting an isothiocyanate compound of the general formula Hal.CH(R.sub.1). CH.dbd.C(R.sub.2).NCS in which Hal is a chlorine or bromine atom and R.sub.1 and R.sub.2 is each a hydrogen atom or an alkyl group containing 1 to 3 carbon atoms, in solution with a chlorinating or brominating agent. The compound 2-chloro-5-(chloromethyl) thiazole, which is an important intermediate in the manufacture of agrochemical and pharmaceutical products, may very advantageously be prepared by this method.
Claims18
A process for the preparation of a substituted thiazole, which process comprises reacting an isothiocyanate compound of the general formula
- Hal.CH(R.sub.1). CH.dbd.C(R.sub.2). NCS,
- wherein the symbol Hal represents a chlorine atom or a bromine atom and the symbols R.sub.1 and R.sub.2 each represents a hydrogen atom or an alkyl group containing from 1 to 3 carbon atoms, in solution, with a chlorinating agent or a brominating agent.
A process for the preparation of 2-chloro-5-(chloromethyl) thiazole, which process comprises reacting 3-chloroprop-1-enyl isothiocyanate with a chlorinating agent, in solution in a solvent.
A process for the preparation of 2-chloro-5-(chloromethyl) thiazole, which process comprises reacting 3-chloroprop-1-enyl isothiocyanate with sulphuryl chloride, the reaction being carried out in a chlorinated hydrocarbon solvent selected from the group comprising dichloromethane, chloroform, 1,2-dichloroethane, 1,1,2-trichloroethane, 1,2,3-trichloropropane, 1,1,2,2-tetrachloroethane and chlorobenzene.
Dependencies are inferred from the claim text.