Substituted pyrazoles as CRF antagonists

A compound of the formula ##STR26## and the pharmaceutically acceptable acid addition salts thereof, wherein R.sub.1 is hydrogen;

• linear or branched C.sub.1 -C.sub.6 alkyl;
• C.sub.3 -C.sub.6 alkyl containing one or two non-adjacent double bonds;
• hydroxy;
• O(C.sub.1 -C.sub.6 alkyl);
• SH;
• S (C.sub.1 -C.sub.6 alkyl);
• or C.sub.3 -C.sub.6 cycloalkyl;
• morpholinyl, piperdinyl or aryl which aryl may be substituted by one to three of fluoro, chloro, bromo, hydroxy, O(C.sub.1 -C.sub.6 alkyl), SH, S(C.sub.1 -C.sub.6 alkyl), amino, NH(C.sub.1 -C.sub.6 alkyl), N(C.sub.1 -C.sub.6 alkyl).sub.2, or one of iodo, nitro or cyano, said aryl being selected from the group consisting of phenyl, thienyl, benzothienyl, pyridyl, quinolyl, pyrazinolyl, pyrimidyl, imidazolyl, benzimidazolyl, furanyl, benzofuranyl, thiazolyl, benzothiazolyl, isothiazolyl, benzoisothiazolyl, isoxazolyl, benzisoxazolyl, triazolyl, pyrazolyl, pyrrolyl, indolyl, azaindolyl, oxazolyl, benzoxazolyl, pyrrolidinyl, or thiazolidinyl;
• R.sub.3 is linear C.sub.1 -C.sub.6 alkyl, branched C.sub.3 -C.sub.8 alkyl, C.sub.3 -C.sub.8 alkenyl wherein the double bond is not adjacent to X.sub.1 when X.sub.1 is a heteroatom, C.sub.3 -C.sub.7 cycloalkyl(CH.sub.2).sub.n wherein n is 0 to 4, or (CH.sub.2).sub.q Q.sub.1 R.sub.19 wherein q is 0, 1 or 2, Q.sub.1 is O, S, NH, N(C.sub.1 -C.sub.6 alkyl), or a covalent bond when X.sub.1 is not a covalent bond, and R.sub.19 is hydrogen, linear C.sub.1 -C.sub.6 alkyl, branched C.sub.3 -C.sub.8 alkyl, C.sub.3 -C.sub.8 alkenyl, C.sub.3 -C.sub.6 cycloalkyl or C.sub.3 -C.sub.6 cycloalkyl-(CH.sub.2) with the proviso that when q is 1, then X.sub.1 and Q.sub.1 cannot both be a heteroatom;
• X.sub.1 is a covalent bond, CH.sub.2, O, S, or NR, wherein R is hydrogen, linear C.sub.1 -C.sub.6 alkyl or branched C.sub.3 -C.sub.8 alkyl;
• Y is phenyl, thienyl, benzothienyl, pyridyl, quinolyl, pyrazinolyl, pyrimidyl, imidazolyl, benzimidazolyl, furanyl, benzofuranyl, thiazolyl, benzothiazolyl, isothiazolyl, benz isothiazolyl, isoxazolyl, benz isoxazolyl, triazolyl, pyrazolyl, pyrrolyl, indolyl, azaindolyl, oxazolyl, benzoxazolyl, pyrrolidinyl, thiazolidinyl, morpholinyl, or piperidinyl, each of which may be substituted by one to three of any one of fluoro, chloro, bromo, or methyl, or one of trifluoromethyl;
• with the proviso that Y is not unsubstituted phenyl;
• R.sub.4 is hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, hydroxy, fluoro, chloro, bromo, iodo or trifluoromethyl;
• R.sub.5 is hydrogen, linear C.sub.1 -C.sub.6 alkyl, branched C.sub.3 -C.sub.8 alkyl, C.sub.3 -C.sub.8 alkenyl, or (CH.sub.2).sub.0 --X.sub.2 --(CH.sub.2).sub.r --Q.sub.2 --R.sub.6 ;
• X.sub.2 and Q.sub.2 are each independently O, S, NH, N(C.sub.1 -C.sub.6 alkyl), or one of X.sub.1 and Q.sub.2 may be a covalent bond;
• R.sub.6 is hydrogen, linear C.sub.1 -C.sub.6 alkyl, branched C.sub.3 -C.sub.8 alkyl, or C.sub.3 -C.sub.8 alkenyl;
• o is 1 or 2;
• and
• r is 0, 1 or 2.