Hereroaryl derivatives of monocyclic beta-lactam antibiotics

A compound of the formula ##STR36## wherein R.sub.6 and R.sub.7 are protecting groups.

A compound of the formula ##STR37## wherein R.sub.6, R.sub.7 and R.sub.13 are protecting groups and n is the integer of three or four.

A compound of formula ##STR38## wherein R.sub.6 /R.sub.6 is C(CH.sub.3).sub.2 taken together with the oxygen atoms to which they are attached forming a 5-membered dioxolane ring and R.sub.7 is tert-butyl.

A compound of formula ##STR39## wherein R.sub.6 /R.sub.6 is C(CH.sub.3).sub.2 taken together with the oxygen atoms to which they are attached forming a 5-membered dioxolane ring;

• R.sub.13 is acetyl or benzyl and R.sub.7 is tert-butyl.

A compound of the formula ##STR40## wherein R.sub.6 and R.sub.7 are protecting groups;

• Z is a hydroxy or a leaving group;
• X is --(CH.sub.2).sub.n -- wherein n is 0, 1, 2, 3 or 4 or CR.sub.3 R.sub.4 wherein R.sub.3 and R.sub.4 are the same or different and each is hydrogen, --CH.sub.3 or --C.sub.2 H.sub.5 or R.sub.3 and R.sub.4 taken together with the carbon atom to which they are attached form a 3, 4, 5, 6 or 7-membered cycloalkyl ring.

A compound of formula ##STR41## wherein R.sub.6 and R.sub.7 are protecting groups;

• R.sub.3 and R.sub.4 taken together with the carbon atom to which they are attached form a 3, 4, 5, 6 or 7-membered cycloalkyl ring.

A compound of formula ##STR42## wherein R.sub.6 /R.sub.6 is C(CH.sub.3).sub.2 taken together with the oxygen atoms to which they are attached forming a 5-membered dioxolane ring, R.sub.7 is tert-butyl;

• X is --(CH.sub.2).sub.n -- wherein n is an integer from one to four and Z is hydrogen.

A compound of formula ##STR43## wherein R.sub.6 /R.sub.6 is C(CH.sub.3).sub.2 taken together with the oxygen atoms to which they are attached forming a 5-membered dioxolane ring;

• R.sub.3 and R.sub.4 are hydrogen and R.sub.7 is t-butyl.