2'-methylidenepyrimidine nucleoside compounds
AssigneesYoshitomi Pharmaceutical Industries, Ltd., Yamasa Shoyu Kabushiki Kaisha
InventorsTohru Ueda, Takuma Sasaki, Akira Matsuda, Keiji Yamagami, Akihiro Fujii
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AssigneesYoshitomi Pharmaceutical Industries, Ltd., Yamasa Shoyu Kabushiki Kaisha
InventorsTohru Ueda, Takuma Sasaki, Akira Matsuda, Keiji Yamagami, Akihiro Fujii
Estimating the term…
2'-Methylidenepyrimidine nucleoside compounds of the general formula: ##STR1## wherein R.sup.1 stands for amino or hydroxy group; R.sup.2 stands for a halogen or a lower alkyl when R.sup.1 is amino or R.sup.2 stands for an alkyl having 2 to 4 carbon atoms, an alkynyl having 2 to 4 carbon atoms or a haloalkyl when R.sup.1 is hydroxy group; and R.sup.3 stands for hydrogen or a phosphoric acid residue, or salts thereof, anticancer compositions containing one or more of these compounds and methods for production of these compounds. Said compounds and salts thereof exhibit noticeable antitumor activities and are useful as anticancer agents.
A 2'-methylidenepyrimidine nucleoside selected from the group consisting of (1) a compound of the formula ##STR6## wherein R.sup.3 is hydrogen, (2) a salt of said compound and (3) a hydrate of said compound.
Dependencies are inferred from the claim text.