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US 5,705,606 AGranted
Peptides derived from GPIIIa
AssigneeCOR Therapeutics, Inc.
InventorsIsrael F. Charo, Laurence A. Fitzgerald, David R. Phillips
Life of this patent
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Abstract
The present invention provides oligopeptides corresponding to regions of the GPIIIa protein, which are capable of specifically binding aggregation mediators, such as fibrinogen. The oligopeptides will typically comprise at least about 5 to 20 amino acids, and are thus non-immunogenic and easy to produce, formulate and administer.
Claims6
An isolated and purified oligopeptide comprising the amino acid sequence:
- Glu-Glu-Val-Lys-Lys-Gln-Ser-Val-Ser-Arg-Asn-Arg-Asp-Ala-Pro-Glu-Gly-Gly-Phe -Asp (SEQ ID NO.:9);
- Asn-Glu-Glu-Val-Lys-Lys-Gln-Ser-Val-Ser-Arg-Asn-Arg-Asp-Ala-Pro-Glu-Gly-Gly -Phe-Asp-Ala-Ile-Met-Gln-Ala (SEQ ID NO.:11);
- Asn-Glu-Glu-Val-Lys-Lys-Gln-Ser-Val-Ser-Arg-Asn-Arg-Asp-Ala-Pro-Glu-Gly-Gly (SEQ ID NO.:12);
- Ser-Val-Ser-Arg-Asn-Arg-Asp-Ala-Pro-Glu-Gly-Gly-Phe-Asp-Ala-Ile-Met-Gln-Ala (SEQ ID NO.:13);
- or
- Ser-Val-Ser-Arg-Asn-Arg-Asp-Ala-Pro-Glu-Gly-Gly;
- (SEQ ID NO.:14)
- wherein the oligopeptide has less than about 50 continuous amino acids from the naturally occurring GPIIIa sequence.
5 more elements
Dependencies are inferred from the claim text.