1,5-disubstituted 7A-methylperhydroinden-3A-ol derivatives, useful in treating cardiovascular disorders, processes for their preparation and pharmaceutical compositions containing the same

A composition, comprising:

• (a) a pharmaceutically acceptable carrier and/or diluent;
• and
• (b) a 1,5 disubstituted 5a-methylperhydroinden-3a-ol derivative of formula (I), or a pharmaceutically acceptable salt thereof:
• ##STR8## wherein:
• either
• the symbol - - - - represents a single bond,
• the group A is in cis configuration with respect to the 3a-hydroxy, 7a-methyl and 1-L groups, and
• A is (CH.dbd.CH).sub.m (CH.sub.2).sub.n OR, (CH.dbd.CH).sub.m (CH.sub.2).sub.n NR.sup.1 R.sup.2, (CH.dbd.CH).sub.m (CH.sub.2).sub.p B, OH, O(CH.sub.2).sub.q OR, O(CH.sub.2).sub.q NR.sup.1 R.sup.2 or O(CH.sub.2).sub.r B;
• q is an integer from 2 to 5;
• r is an integer from 1 to 2;
• or the symbol - - - - represents a double bond,
• A is oxygen, CH(CH.dbd.CH).sub.s (CH.sub.2).sub.n OR, CH(CH.dbd.CH).sub.s (CH.sub.2).sub.n NR.sup.1 R.sup.2 or CH(CH.dbd.CH).sub.s (CH.sub.2).sub.p B;
• R is hydrogen, unsubstituted C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 alkyl substituted by NR.sup.1 R.sup.2 ;
• either
• R.sup.1 and R.sup.2, which may be the same or different, are independently hydrogen or C.sub.1 -C.sub.4 alkyl;
• B is a five-membered unsaturated or six-membered unsaturated or saturated monocarbocyclic ring, and the monocarbocycle may be unsubstituted or substituted by one or more substituents selected from the group consisting of C.sub.1 -C.sub.4 alkyl, halogen, (CH.sub.2).sub.m OR, and (CH.sub.2).sub.m, NR.sup.1 R.sup.2 ;
• n is an integer from 1 to 6;
• p is an integer from 0 to 2;
• m is an integer from 0 to 2;
• L is ›CH.dbd.C(R.sup.3)!.sub.s CH.dbd.NR.sup.4 or ›CH.dbd.C(R.sup.3)!.sub.s CH.sub.2 NHR.sup.4, in the E configuration;
• s is 0 or 1;
• R.sup.3 is hydrogen or CH.sub.3 ;
• R.sup.4 is NHC(.dbd.NR.sup.5)NR.sup.6 R.sup.7 or OR.sup.8 ;
• the symbol represents a Z or E configuration;
• R.sup.s is hydrogen or C.sub.1 -C.sub.4 alkyl, R.sup.6 and R.sup.7 which may be the same or different, are independently hydrogen, unsubstituted C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 substituted by NR.sup.9 R.sup.10 ;
• R.sup.8 is hydrogen, CH.sub.3, unsubstituted C.sub.2 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkyl substituted with NR.sup.9 R.sup.10 or NHC(.dbd.NH)NH.sub.2 ;
• and
• R.sup.9 and R.sup.10, which may be the same or different, are independently hydrogen or C.sub.1 -C.sub.4 alkyl.