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AssigneeSankyo Company, Limited
InventorsSadao Ishihara, Fujio Saito, Takao Yoshioka, Hiroyuki Koike, Shigeki Miyake, Hiroshi Mizuno
Estimating the term…
An amino acid compound of the formula: R.sup.1 NH--CH(R.sup.2)--COHN--A--ONO.sub.2, wherein R.sup.1 represents a hydrogen atom, a C.sub.1 -C.sub.7 alkanoyl group, a C.sub.1 -C.sub.6 alkoxycarbonyl group, a C.sub.6 -C.sub.10 arylcarbonyl group, a C.sub.7 -C.sub.13 aralkylcarbonyl group, a C.sub.7 -C.sub.13 aralkyloxycarbonyl group or a 5- or 6-membered aromatic heterocyclic carbonyl group; R.sup.2 represents a substituted C.sub.1 -C.sub.6 alkyl group; and A represents a C.sub.2 -C.sub.5 alkylene group; and pharmacologically acceptable salts thereof. The amino acid compound has an excellent vasodilator action for collateral vessels and is useful for treating angina pectoris.
An amino acid compound of the following formula (I):
N-(2-Nitrooxyethyl)-2-amino-3-mercaptopropanamide and pharmacologically acceptable salts thereof.
N-(2-Nitrooxyethyl)-2-acetylamino-3-mercaptopropanamide and pharmacologically acceptable salts thereof.
N-(2-Nitrooxyethyl)-2-acetylamino-3-acetylthiopropanamide and pharmacologically acceptable salts thereof.
N-(2-Nitrooxyethyl)-2-acetylamino-3-pivaloylthiopropanamide and pharmacologically acceptable salts thereof.
N-(2-Nitrooxyethyl)-2-acetylamino-3-ethoxycarbonylthiopropanamide and pharmacologically acceptable salts thereof.
N-(2-Nitrooxyethyl)-2-acetylamino-3-benzoylthiopropanamide and pharmacologically acceptable salts thereof.
N-(2-Nitrooxyethyl)-2-isobutyrylamino-3-isobutyrylthiopropanamide and pharmacologically acceptable salts thereof.
N-(2-Nitrooxyethyl)-2-acetylamino-3-(5-m ethyl-2-oxo-1,3-dioxolen-4-yl)methoxycarbonylthiopropanamide and pharmacologically acceptable salts thereof.
Dependencies are inferred from the claim text.