Compounds having anti-inflammatory and anti-viral activity, compositions of these, alone and in combination with reverse transcriptase inhibitors

A method of treating HIV infected and AIDS patients comprising administering to the patients a compound of the following linear or cyclic formula:

• ##STR11## wherein R.sup.1 is an alkyl group of from 1 to 4 carbon atoms optionally mono-, -di, or tri-substituted with halogen;
• each of R.sup.2, R.sup.3, and R.sup.4 is hydrogen, or a straight or branched alkyl radical containing 1 to 8 carbon atoms, an alkenyl radical containing 2 to 8 carbon atoms, an alkynyl radical containing 2 to 8 carbon atoms, a cycloalkyl radical containing 3 to 6 carbon atoms, a cycloalkenyl radical containing from 4 to 6 carbon atoms or a bicycloalkyl radical containing 7 to 11 carbon atoms, these radicals optionally being substituted by at least one substituent selected from halogen, hydroxyl, alkyloxy containing 1 to 4 carbon atoms, dialkyl amino, in which each alkyl contains 1 to 4 carbon atoms, phenyl alkyl in which the alkyl contains 1 to 4 carbon atoms, cyclo alkyl containing 3 to 6 carbon atoms, optionally substituted phenyl, cyano, carboxyl, or alkyloxy carbonyl in which the alkyl contains 1 to 4 carbon atoms;
• n is an integer from 0 to 6 for formula I and n=1 for formula II;
• and salts thereof, in combination with at least one reverse transcriptase inhibitor.

A D-compound of the formulae:

• ##STR12## wherein R.sup.1 is an alkyl group of from 1 to 4 carbon atoms optionally mono-, -di, or tri-substituted with halogen;
• each of R.sup.2, R.sup.3, and R.sup.4 is hydrogen, or a straight or branched alkyl radical containing 1 to 8 carbon atoms, an alkynyl radical containing 2 to 8 carbon atoms, an alkenyl radical containing 2 to 8 carbon atoms, a cycloalkyl radical containing 3 to 6 carbon atoms, a cycloalkenyl radical containing from 4 to 6 carbon atoms or a bicycloalkyl radical containing 7 to 11 carbon atoms, these radicals optionally being substituted by at least one substituent selected from halogen, hydroxyl, alkyloxy containing 1 to 4 carbon atoms, dialkyl amino, in which each alkyl contains 1 to 4 carbon atoms, phenyl alkyl in which the alkyl contains 1 to 4 carbon atoms, cyclo alkyl containing 3 to 6 carbon atoms, optionally substituted phenyl, cyano, carboxyl, or alkyloxy carbonyl in which the alkyl contains 1 to 4 carbon atoms;
• n is an integer from 0 to 6 for formula I and n=1 for formula II;
• and salts thereof.

A method of treating asthma comprising administering to patients in need of treatment an effective amount of a compound of the following linear or cyclic formula:

• ##STR13## wherein R.sup.1 is an alkyl group of from 1 to 4 carbon atoms optionally mono-, -di, or tri-substituted with halogen;
• each of R.sup.2, R.sup.3, and R.sup.4 is hydrogen, or a straight or branched alkyl radical containing 1 to 8 carbon atoms, an alkenyl radical containing 2 to 8 carbon atoms, an alkynyl radical containing 2 to 8 carbon atoms, a cycloalkyl radical containing 3 to 6 carbon atoms, a cycloalkenyl radical containing from 4 to 6 carbon atoms or a bicycloalkyl radical containing 7 to 11 carbon atoms, these radicals optionally being substituted by at least one substituent selected from halogen, hydroxyl, alkyloxy containing 1 to 4 carbon atoms, dialkyl amino, in which each alkyl contains 1 to 4 carbon atoms, phenyl alkyl in which the alkyl contains 1 to 4 carbon atoms, cyclo alkyl containing 3 to 6 carbon atoms, optionally substituted phenyl, cyano, carboxyl, or alkyloxy carbonyl in which the alkyl contains 1 to 4 carbon atoms;
• n is an integer from 0 to 6 for formula I and n=1 for formula II;
• and salts thereof.