Method of activating photosensitive agents
AssigneeThe University of British Columbia
InventorsAnna M. Richter, Elizabeth Waterfield, Julia G. Levy
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Abstract
A method of administering photodynamic therapy begins with administering to an animal an effective amount of a photosensitizing agent which is less than about one half of the usual clinical dose for the photosensitizing agent. Then, following a post injection interval which is less about one quarter of the usual post injection interval, an effective dose of light which is less than about one half of the usual clinical dose of light used in conjunction with the photosensitizing agent is administered to the animal.
Claims11
A method to destroy or impair an area of neovascularization in an animal, which animal comprises both an area of neovascularization and normal tissue, which method comprises:
- (a) administering to said animal an effective amount of a photosensitizing agent;
- (b) transcutaneously administering to said area of neovascularization an effective amount of light of a wavelength that matches an excitation wavelength of said photosensitizing agent,
- wherein said light is administered to said area of neovascularization before said photosensitizer has permeated said normal tissue, thus substantially avoiding skin photosensitivity;
- and wherein the post-injection time between step (a) and step (b) varies between about one minute and three hours.
A method to destroy or impair a solid tumor in an animal, which animal comprises both solid tumor and normal tissue, which method comprises:
- (a) administering to said animal an effective amount of benzoporphyrin derivative-monoacid (BPD-MA);
- and
- (b) transcutaneously administering to said tumor an effective amount of light of a wavelength that matches an excitation wavelength of said BPD-MA, wherein said light is administered to said tumor before said BPD-MA has permeated said normal tissue, thus substantially avoiding skin photosensitivity;
- and wherein the post-injection time between step (a) and step (b) varies between about one minute and 45 minutes.
Dependencies are inferred from the claim text.