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US 5,705,497 AGranted
3-alkoxycarbonyl-thiadiazinones
AssigneeMerck Patent GmbH
InventorsRochus Jonas, Inge Lues, Norbert Beier, Klaus-Otto Minck
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Abstract
3-Alkoxycarbonyl thiadiazinones of the formula I ##STR1## and physiologically unobjectionable salts thereof, in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, Q and n have the meanings described herein, exhibit a positively inotropic action and can be employed for the therapy of cardiac insufficiency.
Claims25
A 3-alkoxycarbonylthiadiazinone compound of the formula I ##STR5## in which R.sup.1, R.sup.2 and R.sup.3 are each independently of one another H or A,
- R.sup.4 is an acyl radical of a carboxylic or sulfonic acid having 1 to 15 carbon atoms,
- R.sup.5 is NH.sub.2, NHA, NA.sub.2 or a saturated three- to eight-membered heterocyclic radical having at least one nitrogen atom in the ring through which the radical is bonded, which radical can be substituted by A and in which, additionally, a further CH.sub.2 group in the ring can be replaced by an NH or NA group or an oxygen or sulfur atom,
- Q is absent or is branched or unbranched alkylene having 1 to 10 carbon atoms,
- n is 1, 2 or 3, and
- A is alkyl having 1 to 6 carbon atoms,
- and the physiologically acceptable salts thereof.
3 more elements
Dependencies are inferred from the claim text.