3'-O-aminoacyl ARA uridines, method of making, and antiviral activity
AssigneeHoffmann-La Roche Inc.
InventorsJoseph Armstrong Martin, Gareth John Thomas
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Abstract
Pyrimidine nucleoside derivatives of formula ##STR1## wherein R.sup.1 represents aryl, R.sup.2 represents lower alkyl, R.sup.3 represents an acyl group derived from an amino acid and R.sup.4 represents hydrogen or fluorine and the asterisk denotes that the configuration at the carbon atom indicated thereby is (S) or (R), are disclosed. These compounds, as well as their salts, are useful as antiviral agents.
Claims14
A compound of the formula ##STR4## wherein R.sup.1 represents aryl,
- R.sup.2 represents lower alkyl,
- R.sup.3 represents an acyl residue of an amino acid,
- R.sup.4 represents hydrogen or fluorine, and the asterisk denotes that the configuration at the carbon atom indicated thereby is (S) or (R),
- and pharmaceutically acceptable acid addition salts thereof.
The compound 1-5-2(S)-(2,4-Dichloro-5-methoxyphenoxy)-propionamido!-2,5-dideoxy-2-flu oro-3-O-L-valyl-.beta.-D-arabinofuranosyl!-5-ethyluracil.
The compound 1-5-2(R)-(2,4-Dichloro-5-methoxyphenoxy)-propionamido!-2,5-dideoxy-2-flu oro-3-O-L-valyl-.beta.-D-arabinofuranosyl!-5-ethyluracil.
Dependencies are inferred from the claim text.