Bisconjugates comprising two saccharides and a spacer
AssigneesAkzo Nobel N.V., Elf Sanofi
InventorsConstant A. A. Van Boeckel, Peter D. J. Grootenhuis, Maurice Petitou, Pieter Westerduin
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Abstract
The invention relates to a tuneable bisconjugate comprising two saccharides and a spacer, each saccharide being the same or different and comprising two to six monosaccharide units, at least one unit being uronic acid, characterized in that at least one of the saccharides per se has anti-thrombotic activity, and that the spacer connects at least one saccharide to the other through its non-reducing end, the chain length of the spacer being 20-120 atoms.
Claims12
A bis/mixed conjugate consisting of two saccharides and a spacer, each saccharide being the same or different and comprising two to six monosaccharide units, at least one unit being uronic acid, wherein at least one of the saccharides per se has anti-thrombotic activity, and the spacer connects at least one saccharide to the other through its non-reducing end, the chain length of the spacer consisting of at least twenty atoms.
Dependencies are inferred from the claim text.