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US 5,705,389 AGranted
Oligonucleotides that inhibit production of .alpha.-tumor necrosis factor
AssigneeRoussel Uclaf
InventorsAbdel Karim Braham, Pierre Smets, Rene Zalisz
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Abstract
A sequence of anti-direction, anti-messenger RNA oligonucleotides of .alpha.-TNF characterized in that it possesses the structure of the formula ##STR1## wherein X is hydrogen, or a sequence of 1 to 17 oligonucleotides in free form, in alkylated form, in sulfurated form or in the form of a poly L-lysine derivative useful for stopping the production of .alpha.-TNF.
Claims9
A sequence of anti-direction, anti-messenger RNA oligonucleotides of .alpha.-TNF characterized in that it possesses the structure of the formula
- 5'TCA TGG TGT CCT TTG CAG-N 3' (SEQ ID NO:1)
- wherein N is a hydrogen atom,
- or a sequence of the formula 5' CC 3',
- or a sequence of the formula 5' CC TCA TGC TTT CAG TAG 3', and wherein some of the phosphate groups are in free form, in alkylated form, in thiolate or dithiolate form, or in the form of poly-L-lysine derivative.
1 more element
Dependencies are inferred from the claim text.