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US 5,705,377 AGranted
Tyrosine kinase
AssigneeThe Salk Institute for Biological Studies
InventorMerl F. Hoekstra
Life of this patent
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Abstract
Tyrosine kinase mutant and wild-type genes useful in screening compositions which may affect DNA double-strand break repair activity.
Claims6
An isolated polynucleotide encoding the S. cerevisiae HRR25 protein kinase polypeptide of Sequence I.D. No. 2.
An isolated polynucleotide encoding the polypeptide of Sequence I.D. No. 2 wherein an aspartic acid residue replaces the glycine residue at position 151.
An isolated polynucleotide encoding only a polypeptide having greater than 35 percent amino acid sequence homology to the protein kinase domain amino acid residues 1-287 of SEQ ID NO:
- 2, wherein said polypeptide:
- a) possesses protein kinase activity;
- b) promotes normal mitotic recombination;
- and
- c) promotes repair of a DNA strand break occurring at an HO endonuclease site.
2 more elements
Dependencies are inferred from the claim text.