Recombinant production of human interferon .tau. polypeptides and nucleic acids
AssigneeThe Women's Research Institute
InventorKazuhiko Imakawa
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Abstract
The present invention describes the production of interferon-.tau. proteins and polypeptides derived therefrom. The antiviral and anticellular proliferation properties of these proteins and polypeptides are disclosed. One advantage of the proteins of the present invention is that they do not have cytotoxic side-effects when used to treat cells. Structure/function relationships for the interferon-.tau. protein are also described. In one aspect, the invention includes ovine interferon-.tau.. In another aspect the invention includes multiple forms of human interferon-.tau..
Claims19
An isolated and purified nucleic acid molecule which comprises an open reading frame that encodes a human interferon-.tau. polypeptide and that has the nucleotide sequence of:
- (a) the coding sequence of a DNA molecule present in a human library, wherein said coding sequence exhibits at least 95% identity to the coding sequence set forth in SEQ ID NO:
- 43, 29, 33, 25, 27, 21, or 23;
- or
- (b) a nucleic acid molecule which is degenerate with the DNA molecule of (a).
An isolated and purified nucleic acid molecule comprising an open reading frame which encodes an interferon-.tau. polypeptide that comprises the amino acid sequence presented as SEQ ID NO:
- 44.
An isolated and purified nucleic acid molecule comprising an open reading frame which encodes an interferon-.tau. polypeptide that comprises the amino acid sequence presented as SEQ ID NO:
- 30, wherein Xaa represents any amino acid.
An isolated and purified nucleic acid molecule comprising an open reading frame which encodes an interferon-.tau. polypeptide that comprises the amino acid sequence presented as SEQ ID NO:
- 34.
An isolated and purified nucleic acid molecule which comprises the nucleotide sequence presented as SEQ ID NO:
- 25.
An isolated and purified nucleic acid molecule which comprises the nucleotide sequence presented as SEQ ID NO:
- 27.
An isolated and purified nucleic acid molecule which comprises the nucleotide sequence presented as SEQ ID NO:
- 21.
An isolated and purified nucleic acid molecule which comprises the nucleotide sequence presented as SEQ ID NO:
- 23.
Dependencies are inferred from the claim text.