Process of continuous preparation of disperse colloidal systems in the form of nanocapsules or nanoparticles

A continuous method for preparing nanospheres comprising:

• (1) mixing under constant stirring and controlled temperature and pH
• (a) an aqueous phase comprising water, and optionally, one or more surface active agents and suspensor agents wherein said agents are, optionally, chemically or biologically active substances;
• and
• (b) an organic phase comprising a solve or a mixture of solvents each having a miscibility in water of greater than 10% or a dielectric point of greater than 15, a biocompatible polymer or monomer or a mixture thereof, and, optionally, a lipid product and a chemically or biologically active substance;
• (c) wherein the mixing continues until the desired phase ratio and reaction medium volume are obtained and a colloid suspension is formed;
• (2) continuously removing the colloid suspension and continuously adding further organic and aqueous phases such that the desired phase ratio and reaction medium volume are maintained;
• (3) introducing the removed colloidal suspension to an evaporator where the organic solvent is continuously removed;
• and
• (4) withdrawing the resultant organic solvent-free suspension including nanospheres from the evaporator.