Process for the production of sulfuric acid semi-esters
AssigneeSchering Corporation
InventorKlaus Junghans
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Abstract
The invention relates to a process for the production of sulfuric acid semi-esters of general formula I RO--SO.sub.2 --OH (I), in which R represents an organic radical, from hydroxy compounds of general formula II R--OH (II), in which R has the same meaning as in formula I, characterized in that the latter is reacted in an inert solvent with a disulfuric acid salt of general formula III O(SO.sub.2 OX).sub.2 (III), in which X symbolizes an alkali metal atom.
Claims3
Process for the production of sulfuric acid semi-esters of general formula I
- RO--SO.sub.2 --OH (I),
- in which
- R represents an organic radical, from hydroxy compounds of general formula II
- R--OH (II),
- in which
- R has the same meaning as in formula I, characterized in that the latter is reacted in an inert solvent with a disulfuric acid salt of general formula III
- O(SO.sub.2 OX).sub.2 (III),
- in which
- X symbolizes an alkali metal atom.
Process for the production of conjugated estrogens of general formula Ia ##STR3## in which the three bonds characterized by . . . . . . symbolize three single bonds, two single bonds and a double bond, or two conjugated double bonds, and
- Y represents a carbonyl group, a hydroxymethylene group, an acyloxymethylene group with up to 8 carbon atoms in the acyl radical or a benzyloxymethylene group, wherein hydroxy steroids of general formula IIa ##STR4## in which bonds . . . . . . . and Y have the same meanings as in formula Ia, are reacted in an inert solvent with a disulfuric acid salt of general formula III
- O(SO.sub.2 OX).sub.2 (III),
- in which
- X symbolizes an alkali metal atom.
Dependencies are inferred from the claim text.