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US 5,703,239 AGranted
Indanylpiperidines as melatonergic agents
AssigneeBristol-Myers Squibb Company
InventorsRonald J. Mattson, John D. Catt
Life of this patent
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Abstract
Certain indanyl piperidines are useful as melatonergic agents and can treat various CNS disorders. They are useful in treating sleep disorders and other conditions related to circadian rhythms.
Claims24
A compound of Formula I:
- ##STR14## wherein:
- R is H, C.sub.1-7 alkoxy, halogen, hydroxyl, C.sub.1-4 haloalkoxy or C.sub.1-4 alkoxyphenyl C.sub.1-7 alkoxy;
- Y is hydrogen or halogen;
- Z is O or S;
- m is 1 or 2;
- and
- R.sup.1 is hydrogen, C.sub.1-6 straight or branched alkyl, C.sub.1-6 straight or branched haloalkyl, C.sub.2-8 alkylthioalkyl, C.sub.2-8 alkyloxyalkyl, C.sub.2-6 straight or branched alkenyl, C.sub.3-5 cycloalkyl, C.sub.3-5 cycloalkenyl, thienyl, furanyl, thiadiazolyl, pyrrolyl, C.sub.1-6 alkylthio or NR.sup.2 R.sup.3, in which R.sup.2 and R.sup.3 are independently hydrogen or C.sub.1-4 alkyl.
4 more elements
Dependencies are inferred from the claim text.