Process and solvate of 2-methyl-thieno-benzodiazepine
AssigneeEli Lilly and Company
InventorsCharles A. Bunnell, Terrence Michael Hotten, Samuel D. Larsen, David Edward Tupper
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Abstract
The invention provides lower alcohol solvates of 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno2,3-b!1,5!benzodiazepine (olanzapine) and a process for making such lower alcohol solvates of olanzapine. The invention provides a method for using such solvates of olanzapine to prepare substantially pure anhydrous Form I 2-methyl-thieno-benzodiazepine.
Claims8
A process for preparing substantially pure Form I olanzapine comprising drying a C.sub.1 -C.sub.3 alcohol solvate of olanzapine, and then crystallizing the dried solvate with one or more solvents selected from ethyl acetate, acetone, 2-propanol, t-butanol, tetrahydrofuran and toluene.
Dependencies are inferred from the claim text.