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US 5,703,097 AGranted
5-pyrrolyl-2-pyridylmethylsulfinyl benzimidazole derivatives
AssigneeIl-Yang Pharm. Co., Ltd
InventorsSu Ung Kim, Dong Yeon Kim, Gi ju Chung, Sung Kol Hong, Sung Jun Park, Sang Hoon Nam, Yong Suk Lee
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Abstract
The present invention relates to a novel compound 5-pyrrolyl-2-pyridylmethylsulfinylbenzimidazole derivative having general formula (I) and its salt, ##STR1## wherein all variables are as defined in the specification. The present invention also relates to a process for preparation of the compound of formula (I), as defined above, and its use as an anti-ulcer agent.
Claims5
A compound having the following formula (I), ##STR19## or a salt thereof, in which X represents S, SO or SO.sub.2,
- R.sub.1 and R.sub.2 independently from each other represent hydrogen or alkyl,
- R.sub.3 represents hydrogen, C.sub.1 -C.sub.8 alkyl, --SR.sub.6, --N(R.sub.7).sub.2, 1-piperidinyl, 4-morpholinyl, 4-methylpiperazin-1-yl, 1-pyrrolidinyl, --OR.sub.6, or --O(CH.sub.2).sub.m --Z, wherein
- R.sub.6 represents C.sub.1 -C.sub.4 alkyl, C.sub.2 -C.sub.4 alkenyl, C.sub.3 -C.sub.10 cycloalkyl, C.sub.2 -C.sub.5 fluoroalkyl, or phenyl or benzyl, each of which independently is substituted with one or more halogen or C.sub.1 -C.sub.4 alkyl or alkoxy optionally substituted with halogen,
- R.sub.7 represents hydrogen or C.sub.1 -C.sub.5 alkyl,
- Z represents a group --O(CH.sub.2).sub.p --OR.sub.8, --O(CH.sub.2).sub.q --R.sub.9 or --O(CH.sub.2).sub.r O(CH.sub.2).sub.s --OR.sub.10, wherein
- p and q independently from each other denote an integer of 1 to 3,
- r and s independently from each other denote an integer of 1 to 5,
- R.sub.8 represents hydrogen, lower alkyl, aryl or aralkyl,
- R.sub.9 represents hydrogen alkoxycarbonyl, or aryl, and
- R10 represents hydrogen or lower alkyl,
- m represents an integer of 2 to 10, and
- R.sub.4 and R.sub.5 independently from each other represent hydrogen or C.sub.1 -C.sub.5 alkyl.
9 more elements
Dependencies are inferred from the claim text.