Oxime derivatives, their preparation and their therapeutic use

A compound of formula (I):

• ##STR15## wherein:
• R.sup.1 represents a hydrogen atom or an alkyl group having from 1 to 6 carbon atoms;
• R.sup.2 represents an alkylene group having from 2 to 6 carbon atoms;
• R.sup.3 represents a hydrogen atom, an alkyl group having from 1 to 6 carbon atoms, an alkoxy group having from 1 to 4 carbon atom, an alkylthio group having from 1 to 4 carbon atoms, a halogen atom, a nitro group, an amino group, a monoalkylamino group having from 1 to 4 carbon atoms, a dialkylamino group whose alkyl groups are the same or different and each has from 1 to 4 carbon atoms, an aryl group having from 6 to 10 carbon atoms in a carbocyclic ring which is unsubstituted or is substituted by at least one of the following substituents .alpha., or an aralkyl group in which an alkyl group having from 1 to 4 carbon atoms is substituted by an aryl group as defined above;
• X represents an aryl group having from 6 to 10 carbon atoms in a carbocyclic ring which is unsubstituted or is substituted by at least one of the following substituents .alpha., or an aromatic heterocyclic group having one or two rings, of which at least one is heterocyclic, said group being unsubstituted or being substituted by at least one of the following substituents .alpha.;
• said substituents .alpha. are selected from the group consisting of:
• alkyl groups having from 1 to 6 carbon atoms;
• halogenated alkyl groups having from 1 to 4 carbon atoms;
• hydroxy groups;
• acyloxy groups having from 1 to 4 carbon atoms;
• alkoxy groups having from 1 to 4 carbon atoms;
• alkylenedioxy groups having from 1 to 4 carbon atoms;
• aralkyloxy groups in which an alkoxy group having from 1 to 4 carbon atoms is substituted by an aryl group having from 6 to 10 carbon atoms in a carbocyclic ring which is unsubstituted or is substituted by at least one of the following substituents .beta.;
• alkylthio groups having from 1 to 4 carbon atoms;
• alkylsulfonyl groups having from 1 to 4 carbon atoms;
• halogen atoms;
• nitro groups;
• amino groups;
• monoalkylamino groups having from 1 to 4 carbon atoms;
• dialkylamino groups, whose alkyl groups are the same or different and each is an alkyl group having from 1 to 4 carbon atoms;
• aralkyl groups in which an alkyl group having from 1 to 4 carbon atoms is substituted by an aryl group having from 6 to 10 carbon atoms in a carbocyclic ring which is unsubstituted or is substituted by at least one of the following substituents .beta.;
• aryl groups having from 6 to 10 carbon atoms in a carbocyclic ring which is unsubstituted or is substituted by at least one of the following substituents .beta.;
• aryloxy groups in which the aryl part has from 6 to 10 carbon atoms in a carbocyclic ring which is unsubstituted or is substituted by at least one of the following substituents .beta.;
• arylthio groups in which the aryl part has from 6 to 10 carbon atoms in a carbocyclic ring which is unsubstituted or is substituted by at least one of the following substituents .beta.;
• arylsulfonyl groups in which the aryl part has from 6 to 10 carbon atoms in a carbocyclic ring which is unsubstituted or is substituted by at least one of the following substituents .beta.;
• arylsulfonylamino groups in which the aryl part has from 6 to 10 carbon atoms in a carbocyclic ring which is unsubstituted or is substituted by at least one of the following substituents .beta., and in which the nitrogen atom is unsubstituted or is substituted by an alkyl group having from 1 to 6 carbon atoms;
• groups of formula --R.sup.X ;
• groups of formula --OR.sup.X ;
• groups of formula --SR.sup.X ;
• groups of formula --SO.sub.2 R.sup.X ;
• and
• groups of formula --N(R.sup.Z)SO.sub.2 R.sup.X ;
• in which R.sup.X represents a pyridyl heterocyclic group or an aromatic heterocyclic ring having 5 ring atoms of which from 1 to 3 are selected from the group consisting of nitrogen, oxygen and sulfur atoms or a fused ring system in which such an aromatic heterocyclic ring is fused to an aryl group having from 6 to 10 carbon atoms in a carbocyclic ring;
• and R.sup.Z represents an alkyl group having from 1 to 6 carbon atoms;
• said substituents .beta. are selected from the group consisting of alkyl groups having from 1 to 6 carbon atoms, halogenated alkyl groups having from 1 to 4 carbon atoms, alkoxy groups having from 1 to 4 carbon atoms, halogen atoms, and alkylenedioxy groups having from 1 to 4 carbon atoms;
• Y represents an oxygen atom, a sulfur atom or a group of formula >N--R.sup.4, in which R.sup.4 represents a hydrogen atom, an alkyl group having from 1 to 6 carbon atoms or an acyl group having from 1 to 8 carbon atoms;
• and
• Z represents a group of formula (Za), (Zb), (Zc) or (Zd):
• ##STR16## and salts thereof with the proviso that at least one of R.sup.3 and X contains a pyridyl group.