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US 5,703,094 AGranted
Quinolone- and naphthyridonecarboxylic acid derivatives
AssigneeBayer Aktiengesellschaft
InventorsUwe Petersen, Michael Ruther, Thomas Schenke, Klaus Dieter Bremm, Rainer Endermann
Life of this patent
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Abstract
The invention relates to new quinolone- and naphthyridonecarboxylic acid derivatives which are substituted in the 7-position by an unsaturated bicyclic amine radical, their salts, processes for their preparation and antibacterial compositions comprising these compounds
Claims9
Compounds of the formula (I)
- T--Q (I)
- in which
- Q denotes a radical of the formula ##STR62## wherein R.sup.1 represents alkyl which has 1 to 4 carbon atoms and is optionally mono- or disubstituted by halogen or hydroxyl, alkenyl having 2 to 4 carbon atoms, cycloalkyl which has 3 to 6 carbon atoms and is optionally substituted by 1 or 2 fluorine atoms, bicyclo1.1.1!-pent-1-yl, 1,1-dimethylpropargyl, 3-oxetanyl, methoxy, amino, methylamino, dimethylamino or phenyl which is optionally mono- or disubstituted by halogen, amino or hydroxyl,
- R.sup.2 represents hydroxyl, alkoxy which has 1 to 3 carbon atoms and is optionally substituted by hydroxyl, methoxy, amino or dimethylamino, benzyloxy or (5-methyl-2-oxo-1,3-dioxo-4-yl)methyloxy, acetoxymethyloxy, pivaloyloxymethyloxy, 5-indanyloxy), phthalidinyloxy, 3-acetoxy-2-oxo-butyloxy, nitromethyl or dialkoxycarbonylmethyl having 1 to 2 carbon atoms in each alkyl part,
- X.sup.1 represents hydrogen, halogen or nitro,
- X.sup.2 represents hydrogen, halogen, amino, hydroxyl, methoxy, mercapto, methyl, halogenomethyl or vinyl,
- A represents N or C--R.sup.7, wherein
- R.sup.7 represents hydrogen, halogen, CF.sub.3, OCH.sub.3, OCHF.sub.2, CH.sub.3, CN, CH.dbd.CH.sub.2 or C.tbd.CH, or together with R.sup.1 can also form a bridge having the structure --.sup.* O--CH.sub.2 --CH--CH.sub.3, --.sup.* S--CH.sub.2 --CH.sub.2 --, --.sup.* S--CH.sub.2 --CH--CH.sub.3, --.sup.* CH.sub.2 --CH.sub.2 --CH--CH.sub.3 or --.sup.* O--CH.sub.2 --N--R.sup.8, wherein the atom labelled with .sup.* is linked to the carbon atom of A and wherein
- R.sup.8 denotes hydrogen, methyl or formyl, and
- T denotes a radical of the formula ##STR63## wherein B represents (CH.sub.2).sub.m --NR.sup.3 R.sup.4 or (CH.sub.2).sub.m --OR.sup.5, wherein
- m represents 0 or 1,
- R.sup.3 represents hydrogen, alkyl which has 1 to 3 carbon atoms and is optionally substituted by hydroxyl, acyl having 1 to 3 carbon atoms or alkoxycarbonyl having 1 to 4 carbon atoms in the alkyl part,
- R.sup.4 represents hydrogen or methyl and
- R.sup.5 represents hydrogen or methyl and
- R.sup.6 represents hydrogen or methyl,
- and pharmaceutically usable hydrates and acid addition salts thereof, as well as the alkali metal, alkaline earth metal, silver and guanidinium salts of the underlying carboxylic acids.
13 more elements
Dependencies are inferred from the claim text.