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US 5,703,091 AGranted
N-substituted azabicycloalkane derivatives, their preparation and use
AssigneeBASF SE
InventorsGerd Steiner, Rainer Munschauer, Liliane Unger, Hans-Jurgen Teschendorf, Thomas Hoger
Life of this patent
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Abstract
Compounds of the formula I ##STR1## where B, R.sup.1, R.sup.2, n and A have the meanings given in the description, and their preparation are described. The novel compounds are suitable for the control of diseases.
Claims3
An N-substituted 3-azabicycloalkane derivative of the formula I ##STR5## where B is a 3-, 5- or 6-membered ring which can contain 1 nitrogen atom and/or 1 oxygen atom and possibly one double bond,
- R.sup.1 is a phenyl group which is unsubstituted or mono- or disubstituted by halogen atoms or C.sub.1 -C.sub.4 -alkyl, trifluoromethyl, hydroxyl, C.sub.1 -C.sub.4 -alkoxy, amino, monomethylamino, dimethylamino, cyano or nitro groups,
- R.sup.2 is a hydrogen atom or a C.sub.1 -C.sub.4 -alkyl radical,
- n is the number 2, 3 or 4,
- A is a hydrogen atom or one of the radicals
- --CO--R.sup.5 or --NR.sup.6 --CO--R.sup.7,
- R.sup.5 is a phenyl group which is unsubstituted or mono- or disubstituted by fluorine, chlorine, bromine or a hydroxyl, nitro, amino, C.sub.1-4 -alkanoylamino, C.sub.1-4 -alkylamino, C.sub.1 -C.sub.4 -alkyl or methoxy group or a naphthyl group which is unsubstituted or substituted by fluorine or chlorine,
- R.sup.6 is a hydrogen atom or a methyl group, and
- R.sup.7 is a phenyl group which is mono- or disubstituted by fluorine, chlorine, bromine, C.sub.1 -C.sub.4 -alkyl, hydroxyl or methoxy or monosubstituted by nitro, cyano, trifluoromethyl, amino, C.sub.1 -C.sub.4 -alkylamino or di-C.sub.1 -C.sub.4 -alkylamino or a thienyl, naphthyl, benzothienyl or indenyl group which is unsubstituted or substituted by fluorine, chlorine or nitro,
- and their salts with physiologically tolerable acids.
6 more elements
Dependencies are inferred from the claim text.