Quinolonecarboxylic acid derivatives, their production and use
AssigneeTakeda Chemical Industries, Ltd.
InventorsAkio Miyake, Masahira Nakamura, Hideto Fukushi
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Abstract
A composition comprises a 1,7-disubstituted-4-oxo-3-quinolinecarboxylic acid or 1,7-disubstituted-4-oxo-3-naphthyridinecarboxylic acid derivative which is useful as a prophylactic and/or therapeutic agent for peripheral arterial obstruction, acute myocardial infarction, an antitumor agent, and as a prophylactic and/or therapeutic agent for osteoporosis.
Claims8
A compound of the formula:
- ##STR197## wherein R.sup.1 is hydrogen or a carboxy protecting group;
- R.sup.3 is 4-(4-pyridyl)piperazin-1-yl group;
- 4-(4-piperidinyl)piperidin-1-yl group;
- or a group represented by the formula:
- ##STR198## wherein n.sup.3 is an integer of 1 to 4;
- n.sup.4 is 0 or 1;
- and n.sup.5 is a whole number 0 to 3;
- R.sup.14 and R.sup.15 are hydrogen or halogen;
- R.sup.17 is an optionally substituted phenyl group;
- or a salt thereof.
1-Benzyl-6,8-d ifluoro-7-(1-piperazinyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid.
1-(4-Chlorobenzyl)-6,8-difluoro-7-(1-piperazinyl)-1,4-dihydro-4-oxoq uinoline-3-carboxylic acid.
6,8-Difluoro-1-(2-methox ybenzyl)-7-(1-piperazinyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid.
1-(4-methoxybenzyl)-7-(piperazin-1-yl)-1,4-dihydro-4-oxoquinoline-3-carb oxylic acid or a salt thereof.
Dependencies are inferred from the claim text.