Tetrahydrofuran antifungals
AssigneeSchering Corporation
InventorsAnil K. Saksena, Viyyoor M. Girijavallabhan, Raymond G. Lovey, Russell E. Pike, Haiyan Wang, Yi-Tsung Liu, Ashit K. Ganguly, Frank Bennett
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AssigneeSchering Corporation
InventorsAnil K. Saksena, Viyyoor M. Girijavallabhan, Raymond G. Lovey, Russell E. Pike, Haiyan Wang, Yi-Tsung Liu, Ashit K. Ganguly, Frank Bennett
Estimating the term…
A compound represented by the formula I ##STR1## wherein X is independently both F or both Cl or one X is independently F and the other is independently Cl; R.sub.1 is a straight or branched chain (C.sub.3 to C.sub.8) alkyl group substituted by one or two polyetyher ester groups (e.g., a polyether ester convertible in vivo into a hydroxy group) thereof or a pharmaceutically acceptable salt thereof and pharmaceutical compositions thereof useful for treating and/or preventing fungal infections are disclosed.
A compound represented by the formula I ##STR109## wherein X is independently both F or both Cl or one X is independently F and the other is independently Cl;
A compound represented by formula III ##STR110## wherein R.sub.5 is ##STR111## wherein R.sub.13 is a hydroxy group, or a pharmaceutically acceptable salt thereof.
A compound represented by the formula IV ##STR112## wherein R.sub.9 =--*CH(C.sub.2 H.sub.5)CH(R.sub.6)CH.sub.3 or --*CH(CH.sub.3)CH(R.sub.6)CH.sub.3
Dependencies are inferred from the claim text.