Penem compounds
AssigneeSuntory Limited
InventorsHiromitsu Iwata, Takashi Nakatsuka, Rie Tanaka, Masaji Ishiguro
Life of this patent
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Abstract
Antibiotic penem compounds are represented by the following formula: ##STR1## wherein R represents a group of the following formula: ##STR2## in which R.sub.1 is a linear or branched, C.sub.1 -C.sub.6 alkyl group, R.sub.2 is a particular substituted or unsubstituted alkyl, aryl or aralkyl group, n is an integer of 1 or 2, and R.sub.3 represents a specific substituted or unsubstituted alkyl, aryl or aralkyl group. Antibiotic compositions for oral administration are also described.
Claims14
A penem compound of the following formula (I):
- ##STR11## wherein R represents a group of the following formula (II) or (III):
- ##STR12## in which R.sub.1 is a hydrogen atom or a linear or branched, C.sub.1 -C.sub.6 alkyl group or, together with R.sub.2, forms an o-phenylene group;
- R.sub.2 is a C.sub.1 -C.sub.6 alkyl group, a C.sub.6 -C.sub.10 aryl group, a C.sub.7 -C.sub.11 aralkyl group, said R.sub.2 group or a substituted by one or more substituents selected from C.sub.1 -C.sub.6 alkyl groups, C.sub.6 -C.sub.10 aryl groups, C.sub.7 -C.sub.11 aralkyl groups, hydroxyl groups, C.sub.1 -C.sub.6 alkoxyl groups and halogen atoms;
- and
- n is an integer of 1 or 2,
- or ##STR13## in which R.sub.3 represents a C.sub.1 -C.sub.6 alkyl group, a C.sub.6 -C.sub.10 aryl group, a C.sub.7 -C.sub.11 aralkyl group, or a said R.sub.3 group substituted by one or more substituents selected from C.sub.1 -C.sub.6 alkyl groups, C.sub.6 -C.sub.10 aryl groups, C.sub.7 -C.sub.11 aralkyl groups, hydroxyl groups, C.sub.1 -C.sub.6 alkoxyl groups and halogen atoms.
An antibiotic composition, comprising an effective amount of a compound of the following formula (I):
- ##STR14## wherein R represents a group of the following formula (II) or (III):
- ##STR15## in which R.sub.1 is a hydrogen atom or a linear or branched, C.sub.1 -C.sub.6 alkyl group or, together with R.sub.2, forms an o-phenylene group;
- R.sub.2 is a C.sub.1 -C.sub.6 alkyl group, a C.sub.6 -C.sub.10 aryl group, a C.sub.7 -C.sub.11 aralkyl group, or a said R.sub.2 group substituted by one or more substituents selected from C.sub.1 -C.sub.6 alkyl groups, C.sub.6 -C.sub.10 aryl groups, C.sub.7 -C.sub.11 aralkyl groups, hydroxyl groups, C.sub.1 -C.sub.6 alkoxyl groups and halogen atoms;
- and
- n is an integer of 1 or 2,
- or ##STR16## in which R.sub.3 represents a C.sub.1 -C.sub.6 alkyl group, a C.sub.6 -C.sub.10 aryl group, a C.sub.7 -C.sub.11 aralkyl group, or a said R3 group substituted by one or more substituents selected from C.sub.1 -C.sub.6 alkyl groups, C.sub.6 -C.sub.10 aryl groups, C.sub.7 -C.sub.11 aralkyl groups, hydroxyl groups, C.sub.1 -C.sub.6 alkoxyl groups and halogen atoms, and a pharmaceutically-acceptable carrier.
Dependencies are inferred from the claim text.