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US 5,703,067 AGranted
Inhibitors of farnesyl-protein transferase
AssigneeMerck & Co., Inc.
InventorsHiranthi Jayasuriya, Russell B. Lingham, Fernando Pelaez, Manuel Sanchez, Keith C. Silverman, Sheo Bux Singh, Deborah L. Zink
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Abstract
The present invention is directed to steroidal or terpenoidal compounds which inhibit farnesyl-protein transferase (FPTase). The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and treatment of cancer. The compounds of this invention have the following structure: ##STR1##
Claims7
A compound which inhibits farnesyl-protein transferase of the formula I:
- ##STR18## wherein:
- R.sup.1 is:
- a) --OH;
- or
- b) ##STR19## R.sup.3 is hydrogen or C.sub.1-4 alkyl;
- ##STR20## W is O or H.sub.2 ;
- and X is O or (H,CH.sub.3);
- or a pharmaceutically acceptable salt thereof.
5 more elements
Dependencies are inferred from the claim text.