Heteroarylamino and heteroarylsulfonamido substituted 3-benyzlaminomethyl piperidines and related compounds

A compound of the formula ##STR22## or a pharmaceutically acceptable salt thereof, wherein:

• Q is --NH--, --N(C.sub.1 -C.sub.6 alkyl)-, or --SO.sub.2 N(C.sub.1 -C.sub.6 alkyl)-, wherein the foregoing --SO.sub.2 N(C.sub.1 -C.sub.6 alkyl)- moiety attaches to the phenyl group through the nitrogen atom and attaches to R.sup.1 through the sulfur atom;
• W is hydrogen, C.sub.1 -C.sub.6 alkyl, --S(C.sub.1 -C.sub.3 alkyl), halo or C.sub.1 -C.sub.6 alkoxy, wherein the alkyl moieties of the foregoing W groups are optionally substituted with 1 to 3 fluoro substituents;
• R.sup.1 is a heteroaryl group selected from the group consisting of thiazolyoxazolyllyl, thienyl, triazolyl, oxazolyl, oxadiazolyl, thiadiazolyl, imidazolyl, pyridinyl, and pyrimidinyl, wherein said heteroaryl groups are optionally substituted with 1 to 3 substituents independently selected from phenyl, C.sub.1 -C.sub.6 alkyl, halo, and C.sub.1 -C.sub.6 alkoxy wherein the alkyl moieties of said optional substituents are optionally substituted with 1 to 3 fluoro substituents;
• R.sup.3 is group of the formula VII ##STR23## wherein X is (CH.sub.2).sub.q wherein q is an integer ranging from 1 to 6, and m is an integer ranging from 0 to 8;
• R.sup.12 is hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.7 cycloalkyl;
• aryl selected from biphenyl, phenyl, indanyl, and naphthyl;
• heteroaryl selected from thienyl, furyl, pyridyl, thiazolyl, isothiazolyl, oxazolyl, isoxazolyl, triazolyl, tetrazolyl, and quinolyl;
• benzhydryl or --(C.sub.1 -C.sub.6 alkyl)-(phenyl), wherein the foregoing aryl and heteroaryl groups and the phenyl moieties of said (phenyl)C.sub.1 -C.sub.6 alkyl and benzhydryl groups are optionally substituted with 1 to 3 substituents independently selected from halo, nitro, C.sub.1 -C.sub.10 alkyl, C.sub.1 -C.sub.10 alkoxy, amino, (C.sub.1 -C.sub.6 alkoxy)C.sub.1 -C.sub.6 alkyl, --NH(C.sub.1 -C.sub.6 alkyl), --C(O)O(C.sub.1 -C.sub.6 alkyl), --(C.sub.1 -C.sub.6 alkyl)C(O)(C.sub.1 -C.sub.6 alkyl), --OC(O)(C.sub.1 -C.sub.6 alkyl), --(C.sub.1 -C.sub.6 alkyl)C(O)O(C.sub.1 -C.sub.6 alkyl), --(C.sub.1 -C.sub.6 alkoxy)C(O)(C.sub.1 -C.sub.6 alkyl), --C(O)(C.sub.1 -C.sub.6 alkyl), --N(C.sub.1 -C.sub.6 alkyl)(C.sub.1 -C.sub.6 alkyl), --C(O)NH(C.sub.1 -C.sub.6 alkyl), --NHC(O)H, and --NHC(O)(C.sub.1 -C.sub.6 alkyl);
• R.sup.13 is hydrogen, phenyl or C.sub.1 -C.sub.6 alkyl;
• R.sup.14 and R.sup.15 are each independently selected from hydrogen, hydroxy, halo, amino, carboxy, cyano, hydroxy-substituted C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, --(C.sub.1 -C.sub.6 alkyl)-(C.sub.1 -C.sub.6 alkoxy), --NH(C.sub.1.varies.C.sub.6 alkyl), --C(O)O(C.sub.1 -C.sub.6 alkyl), --OC(O)(C.sub.1 -C.sub.6 alkyl), --(C.sub.1 -C.sub.6 alkyl)C(O)(C.sub.1 -C.sub.6 alkyl), --(C.sub.1 -C.sub.6 alkyl)C(O)O(C.sub.1 -C.sub.6 alkyl), --(C.sub.1 -C.sub.6 alkoxy)C(O)(C.sub.1 -C.sub.6 alkyl), --C(O)(C.sub.1 -C.sub.6 alkyl), --N(C.sub.1 -C.sub.6 alkyl)(C.sub.1 -C.sub.6 alkyl), --C(O)NH(C.sub.1 -C.sub.6 alkyl), --NHC(O)H, --NHC(O)(C.sub.1 -C.sub.6 alkyl), and the radicals set forth in the definition of R.sup.12 ;
• R.sup.16 is --NHC(O)R.sup.18, --NHCH.sub.2 R.sup.18, --SO.sub.2 R.sup.18, --CO.sub.2 H or one of the radicals set forth in any of the definitions of R.sup.12, R.sup.14, and R.sup.15 ;
• R.sup.17 is oximino (.dbd.NOH) and R.sup.16 is absent, or R.sup.17 is one of the radicals set forth in any of the definitions of R.sup.12, R.sup.14, and R.sup.15 ;
• and,
• R.sup.18 is C.sub.1 -C.sub.6 alkyl, hydrogen, phenyl or --(C.sub.1 -C.sub.6 alkyl)(phenyl);
• with the proviso that (a) when m is 0, then one of R.sup.16 and R.sup.17 is absent and the other is hydrogen;
• and (b) when R.sup.14 and R.sup.15 are attached to the same carbon atom, then R.sup.14 and R.sup.15 are each independently selected from hydrogen, fluoro, C.sub.1 -C.sub.6 alkyl, hydroxy-substituted C.sub.1 -C.sub.6 alkyl and --(C.sub.1 -C.sub.6 alkyl)-(C.sub.1 -C.sub.6 alkoxy).