Disaccharide ligands for selectins
AssigneeBritish Biotech Pharmaceuticals Limited
InventorsNigel Mark Allanson, Alan Hornsby Davidson
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AssigneeBritish Biotech Pharmaceuticals Limited
InventorsNigel Mark Allanson, Alan Hornsby Davidson
Estimating the term…
Compounds of formula (I), or a salt, solvate or hydrate thereof, wherein Z represents a divalent group selected from those of formulae I(a) to I(g) defined in the specification; Y represents a single bond or a divalent group selected from those of formulae I(h) to I(j) defined in the specification; each Z independently represents hydrogen or a hydroxyl protecting group; R.sup.1 represents hydrogen or a group --CH(OZ)CH.sub.2 (OZ) wherein Z has the meaning defined above; R.sup.2 represents hydrogen, a pharmaceutically acceptable cation, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, or (optionally substituted)phenyl-(C.sub.1-4) alkyl; and R.sup.3 represents hydrogen, C.sub.1-6 alkyl, (C.sub.1-4) alkyl-substituted phenyl or benzoate; and n is 1, 2 or 3. The compounds are ligands of E-, P-, and L-selectins and are useful as anti-inflammatory agents and as agents for the control of tumour metastasis.
A compound of formula (I), or a salt, solvate or hydrate thereof:
Dependencies are inferred from the claim text.