Compositions containing 5-fluoro-2',3'-didehydro-2',3'-dideoxycytidine or a mono-, di-, or triphosphate thereof and a second antiviral agent
AssigneeEmory University
InventorsRaymond F. Schinazi, Dennis C. Liotta
Life of this patent
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Abstract
A method and composition for the treatment of HIV and HBV infections in humans and other host animals is disclosed that includes the administration of an effective amount of a 5-carboxamido or 5-fluoro!-2',3'-dideoxy-2',3'-didehydro-pyrimidine nucleoside or a 5-carboxamido or 5-fluoro!-3'-modified-pyrimidine nucleoside, or a mixture or a pharmaceutically acceptable derivative thereof, including a 5' or N.sup.4 alkylated or acylated derivative, or a pharmaceutically acceptable salt thereof, in a pharmaceutically acceptable carrier.
Claims19
A composition comprising an effective HIV or HBV treatment amount of a compound of the formula:
- ##STR3## wherein R is hydrogen, monophosphate, diphosphate, or triphosphate;
- in combination or alternation with a second compound selected from the group consisting of 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane, 2-hydroxymethyl-5-(cytosin-1-yl)-1,3-oxathiolane;
- 9-4-(hydroxymethyl)-2-cyclopenten-1-yl!-guanine (carbovir), 9-(2-hydroxyethoxy)methyl!guanine (acyclovir) interferon, 3'-deoxy-3'-azidothymidine (AZT), 2',3'-dideoxyinosine (DDI), 2',3'-dideoxycytidine (DDC), (-)-2'-fluoro-5-methyl-.beta.-L-ARAuridine (L-(-)-FMAU) and 2',3'-didehydro-2',3'-dideoxythymidine (D4T).
Dependencies are inferred from the claim text.