High methionine derivatives of .alpha.-hordothionin for pathogen-control
AssigneePioneer Hi-Bred Int'l., Inc.
InventorAragula Gururaj Rao
Life of this patent
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Abstract
Derivatives of .alpha.-hordothionin made by position-specific substitution with methionine residues provide methionine enrichment in plants while retaining the anti-pathogenic activity of the parent compound.
Claims10
A method for killing and inhibiting plant pathogenic microorganisms which are susceptible to a .alpha.-Hordothionin comprising introducing into the environment of the pathogenic microorganisms an anti-microbial amount of a protein having the sequence of SEQUENCE I.D. NO. 3 wherein the amino acid residues at one or more of positions 1,5,8,11,15,17,18,19,22,23,24,30,32, 33,38, and 41 are methionine, and the remainder of the residues at those positions are the residues at the corresponding positions in SEQUENCE I.D. NO. 1.
A method for killing and inhibiting plant pathogens selected from Fusarinm graminearum, Fusarinm moniliforme, Diplodia maydis, Colletototrichnm graminicola, Verticillium alboatrum, Phytophthora megaspermae f.sp. glycinea, Macrophomina phaseolina, Diaporthe phaseolorum cavlivora, Sclerotinia sclerotiornm, Sclerotinia trifoliorum, and Aspergillus flavus, comprising introducing into the environment of the pathogenic microorganisms an anti-microbial amount of a protein having the sequence of SEQUENCE I.D. NO. 3 wherein the amino acid residues at one or more of positions 1,5,8, 11,15,17,18,19,22,23,24,30,32,33,38, and 41 are methionine, and the remainder of the residues at those positions are the residues at the corresponding positions in SEQUENCE I.D. NO. 1.
Dependencies are inferred from the claim text.