Treatment method using recombinantly produced human membrane cofactor protein (MCP)
AssigneeWashington University
InventorJohn P. Atkinson
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Abstract
Human membrane cofactor protein, a protein involved in regulation of complement activity, has been purified to homogeneity. The gene encoding this protein has been retrieved and permits deduction of the entire amino acid sequence and the recombinant production of this material. Pharmaceutical compositions in which MCP is the active ingredient for use in treating antoimmune diseases are also disclosed.
Claims6
A method to treat a disease or condition characterized by enhanced complement activity, which method comprises administering to a subject in need of such treatment an effective amount of isolated human membrane cofactor protein encoded by a DNA which hybridizes under stringent conditions to the complement of the DNA encoding amino acids 1-251 of FIG. 1 expressed in a non-human or human recombinant host cell in admixture with a suitable pharmaceutical excipient.
Dependencies are inferred from the claim text.